Setipiprant

CAS No. 866460-33-5

Setipiprant ( ACT-129968; ACT 129968; KYTH 105; Setipiprant )

Catalog No. M19195 CAS No. 866460-33-5

Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 23 In Stock
10MG 35 In Stock
25MG 65 In Stock
50MG 106 In Stock
100MG 170 In Stock
200MG 250 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Setipiprant
  • Note
    Research use only, not for human use.
  • Brief Description
    Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2).
  • Description
    Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.
  • Synonyms
    ACT-129968; ACT 129968; KYTH 105; Setipiprant
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CRTh2
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    866460-33-5
  • Formula Weight
    402.42
  • Molecular Formula
    C24H19FN2O3
  • Purity
    98%
  • Solubility
    DMSO : ≥ 36 mg/mL; 89.46 mM
  • SMILES
    C1CN(CC2=C1N(C3=C2C=C(C=C3)F)CC(=O)O)C(=O)C4=CC=CC5=CC=CC=C54
  • Chemical Name
    2-(2-(1-naphthoyl)-8-fluoro-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Diamant Z., et al. Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics. Clin Exp Allergy. 2014 Aug;44(8):1044-52.
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