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Sepin-1

CAS No. 163126-81-6

Sepin-1 ( Sepin 1; Sepin1; 2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide )

Catalog No. M27925 CAS No. 163126-81-6

Sepin-1 is a noncompetitive inhibitor of separase with an IC50 of 14.8 μM. Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sepin-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Sepin-1 is a noncompetitive inhibitor of separase with an IC50 of 14.8 μM. Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apoptosis.
  • Description
    Sepin-1 is a noncompetitive inhibitor of separase with an IC50 of 14.8 μM. Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apoptosis.
  • Synonyms
    Sepin 1; Sepin1; 2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    163126-81-6
  • Formula Weight
    223.2
  • Molecular Formula
    C9H9N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1(C)[N+]([O-])=c2ccc(cc2=[N+]1[O-])[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.P F Li, et al. [Inhibitory effect of 2-(N-acetyl-methyl amino)-3',4'-methylenedioxyacetyl-aminophene(SY-640) on covalent binding of carcinogenic benzo(a)pyrene with mouse hepatocyte nuclear DNA]. Yao Xue Xue Bao. 1997 Sep;32(9):663-8.
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