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Sepimostat
CAS No. 103926-64-3
Sepimostat( —— )
Catalog No. M23248 CAS No. 103926-64-3
Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
|
| 10MG | 372 | In Stock |
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| 25MG | 623 | In Stock |
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| 50MG | 887 | In Stock |
|
| 100MG | 1197 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSepimostat
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NoteResearch use only, not for human use.
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Brief DescriptionSepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit.
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DescriptionSepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM.
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In Vitro——
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In VivoSepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect. Animal Model:Male Sprague Dawley rats weighing 150-300?g.Dosage:Intravitreal injection.Administration:1 to 100 nmol/eye.Result:Exhibited neuroprotective effects significantly.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptorNR2B N-methyl-D-aspartate
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Research Area——
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Indication——
Chemical Information
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CAS Number103926-64-3
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Formula Weight373.41
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Molecular FormulaC21H19N5O2
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Purity>98% (HPLC)
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SolubilityDMSO:6.25 mg/mL?(16.74 mM;?Need ultrasonic)
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SMILESC1CN=C(N1)NC2=CC=C(C=C2)C(=O)OC3=CC4=C(C=C3)C=C(C=C4)C(=N)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.
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