Senkyunolide

CAS No. 63038-10-8

Senkyunolide ( —— )

Catalog No. M22589 CAS No. 63038-10-8

Senkyunolide A is a natural product isolated from Ligusticum chuanxiong Hort, with anti-tumor activity.To determine the equilibrium solubility of senkyunoide and its partition coefficients for the n-octanol-water/buffer solution systems,so as to provide a basis for new formulations designing.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Senkyunolide
  • Note
    Research use only, not for human use.
  • Brief Description
    Senkyunolide A is a natural product isolated from Ligusticum chuanxiong Hort, with anti-tumor activity.To determine the equilibrium solubility of senkyunoide and its partition coefficients for the n-octanol-water/buffer solution systems,so as to provide a basis for new formulations designing.
  • Description
    Senkyunolide A is a natural product isolated from Ligusticum chuanxiong Hort, with anti-tumor activity.To determine the equilibrium solubility of senkyunoide and its partition coefficients for the n-octanol-water/buffer solution systems,so as to provide a basis for new formulations designing. METHODS AND RESULTS:A high performance liquid chromatography method was established to detect the concentration of Senkyunolide .The Megres ODS(5 μm,4.6 mm×100 mm)column was adopted,the mobile phase was acetonitrile-water(1:3, v/v)at a flow rate of 1.0 mL/min,and the detection wavelength was 278 nm.The concentration of Senkyunolide in different pH solutions and the partition coefficients for the n-octanol-water and n-octanol-buffer solution systems were detected. The equilibrium solubility reached a maximum of 34.31 mg/mLin water at 37°C.Senk yunolide was instable in solvent systems pH≥9.0.Partition coefficient of Senkyunolidewas 13.43(lg P app=1.13) in the n-octanol-water system;there was no significant effect of pH to partition coefficient of Senkyunolide . CONCLUSIONS:The study showed that Senkyunolide is soluble,the partition coefficient of Senkyunolide is moderate,and the relative molecular mass of Senkyunolide is small.Therefore,we can explain why Senkyunolide can quickly reach into blood and brain.Senkyunolide can be predicted with a good application value.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    63038-10-8
  • Formula Weight
    192.25
  • Molecular Formula
    C12H16O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:117 mg/mL (608.58mM; Need ultrasonic)
  • SMILES
    O=C1O[C@@H](CCCC)C=2CCC=CC1=2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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