Cart
sales@molnova.com
Securinine
CAS No. 5610-40-2
Securinine( (-)-Securinine )
Catalog No. M21463 CAS No. 5610-40-2
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | In Stock |
|
| 10MG | 75 | In Stock |
|
| 25MG | 156 | In Stock |
|
| 50MG | 229 | In Stock |
|
| 100MG | 343 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSecurinine
-
NoteResearch use only, not for human use.
-
Brief Description(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
-
Description(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.(In Vitro):(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.(In Vivo):In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.
-
In Vitro(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily(TNFRSF) genes in the cells stimulated with (-)-Securinine.
-
In VivoIn this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.
-
Synonyms(-)-Securinine
-
PathwayOthers
-
TargetOther Targets
-
RecptorGABAA
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number5610-40-2
-
Formula Weight217.26
-
Molecular FormulaC13H15NO2
-
Purity>98% (HPLC)
-
SolubilityDMSO:2 mg/mL (9.21 mM)
-
SMILESO=C1O[C@](C2)([C@@H](CCCC3)N3[C@@H]2C=C2)C2=C1
-
Chemical Name(6S11aR11bS)-9101111a-tetrahydro-8H-611b-methanofuro[23-c]pyrido[12-a]azepin-2(6H)-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Stefanowicz-Hajduk J et al. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells. PLoS One. 2016 Oct 28;11(10):e0165372.
molnova catalog
related products
-
Ataquimas
Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.
-
Peonidin-3-O-glucosi...
Peonidin-3-O-glucoside chloride has antioxidant activity, is a radical scavenger.
-
Xenopsin 2TFA(51827-...
Xenopsin(2TFA) is a neurotensin-like octapeptide?previously isolated from amphibian skin.The octapeptide xenopsin, previously isolated from amphibian skin, stimulates exocrine pancreatic secretion of bicarbonate and protein in conscious dogs and increases the volume of secretion.
