Cart
sales@molnova.com
San78-130
CAS No. 66018-45-9
San78-130( —— )
Catalog No. M15512 CAS No. 66018-45-9
San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSan78-130
-
NoteResearch use only, not for human use.
-
Brief DescriptionSan78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM.
-
DescriptionSan78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277; inhibits (>80%) only 6 kinases including ALK1, FLT3, FLT4, KDR, MEK2 and MKK6 in a panel of 342 kinases, shows weak inhibition for other ALK isotypes; suppresses the BMP9-induced Smad1/5 pathway by mainly inhibiting ALK1 in C2C12 cells, promotes angiogenesis in both endothelial tube formation and microfluidic chip based 3D angiogenesis assays.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayTGF-beta/Smad
-
TargetTGFBR
-
RecptorTGFBR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number66018-45-9
-
Formula Weight366.41
-
Molecular FormulaC19H26O7
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESOC1=CC(OC)=CC(CCC[C@@H]([C@H](O)C(CCC[C@H](C)O2)=O)O)=C1C2=O
-
Chemical Name(3S,8S,9S)-8,9,16-Trihydroxy-14-methoxy-3-methyl-3,4,5,6,9,10,11,12-octahydro-1Hbenzo[c][1]oxacyclotetradecine-1,7(8H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Cho H, et al. J Med Chem. 2017 Feb 23;60(4):1495-1508.
molnova catalog
related products
-
LY2157299
LY2157299 (Galunisertib) is a potent, specific inhibitor of TGF-β receptor I kinase ((TGF-βRI) with IC50 of 56 nM.
-
VU 0364849
A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.
-
Pirfenidone
Pirfenidone is an inhibitor for?TGF-β?production and TGF-β stimulated collagen production.
