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Sabeluzole

CAS No. 104383-17-7

Sabeluzole( —— )

Catalog No. M34406 CAS No. 104383-17-7

Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 97 Get Quote
5MG 145 Get Quote
10MG 216 Get Quote
25MG 352 Get Quote
50MG 518 Get Quote
100MG 707 Get Quote
500MG 1431 Get Quote
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Biological Information

  • Product Name
    Sabeluzole
  • Note
    Research use only, not for human use.
  • Brief Description
    Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.
  • Description
    Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult albino male rats (270-330 g) induced by Chlordiazepoxide Dosage:5 mg/kg, 25 mg/kg Administration:SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide Result:Showed the positive effects on several learning and memory tasks in rats.Did not influence locomotor and rearing activity of animals during the acquisition session.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Microtubule Associated
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    104383-17-7
  • Formula Weight
    415.52
  • Molecular Formula
    C22H26FN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC1=CC=C(OCC(O)CN2CCC(N(C3=NC=4C=CC=CC4S3)C)CC2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103. ?
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