SY-640

Research use only, not for human use.

SY-640 is a derivative of Acetamide showing potent hepatoprotective effects.

SY-640 is a derivative of Acetamide showing potent hepatoprotective effects.(In Vitro):SY-640 attenuates the increased expression of leukocyte function-associated antigen-1 and inhibits the number of liver-infiltrating cells.(In Vivo):SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640. SY-640 (oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect.

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Proteasome/Ubiquitin

Endogenous Metabolite

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168705-70-2

207.2

C11H13NO3

>98% (HPLC)

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CN(Cc1ccc2OCOc2c1)C(C)=O

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(-20℃)

With Ice Pack

≥ 2 years