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SU16f
CAS No. 251356-45-3
SU16f( SU 16F | 3-substituted indolin-2-one 16f | SU-16F )
Catalog No. M26828 CAS No. 251356-45-3
SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 133 | Get Quote |
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| 10MG | 194 | Get Quote |
|
| 25MG | 321 | Get Quote |
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| 50MG | 477 | Get Quote |
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| 100MG | 689 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSU16f
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NoteResearch use only, not for human use.
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Brief DescriptionSU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively).
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DescriptionSU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.(In Vitro):SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM. SU16f pretreatment causes the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA .
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In VitroSU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .Cell Proliferation Assay Cell Line:SGC-7901 cells in GC-MSC/SGC-7901 co-culture system Concentration:20 μM Incubation Time:8 hours Result:Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. Western Blot Analysis Cell Line:SGC-7901 cells Concentration:20 μM Incubation Time:8 hours Result:Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA.
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In Vivo——
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SynonymsSU 16F | 3-substituted indolin-2-one 16f | SU-16F
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PathwayAngiogenesis
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TargetPDGFR
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RecptorMDM-2/p53
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Research Area——
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Indication——
Chemical Information
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CAS Number251356-45-3
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Formula Weight386.451
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Molecular FormulaC24H22N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (129.39 mM)
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SMILESCc1[nH]c(\C=C2/C(=O)Nc3cc(ccc23)-c2ccccc2)c(C)c1CCC(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chattopadhyay A, et al. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016;6:23732.
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