SRT2104 ( SRT2104; SRT 2104; SRT-2104; GSK2245840 )

Catalog No. M17806 CAS No. 1093403-33-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

SRT2104
Note

Research use only, not for human use.
Brief Description

SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
Description

SRT2104, also known as GSK2245840, is a novel, first-in-class, highly selective small molecule activator of the NAD + dependent deacetylase SIRT1. SRT2104 has been developed as a selective small molecule activator of SIRT1, a NAD(+)-dependent deacetylase involved in the regulation of energy homeostasis and the modulation of various metabolic pathways, including glucose metabolism, oxidative stress and lipid metabolism. SIRT1 has been suggested as putative therapeutic target in multiple age-related diseases including type 2 diabetes and dyslipidemias.
Synonyms

SRT2104; SRT 2104; SRT-2104; GSK2245840
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

SIRT1
Research Area

Cancer
Indication

——

CAS Number

1093403-33-8
Formula Weight

516.64
Molecular Formula

C26H24N6O2S2
Purity

98%
Solubility

DMSO : 5 mg/mL 9.68 mM; H2O : < 0.1 mg/mL
SMILES

Cc1c(sc(n1)c1cnccc1)C(=O)Nc1ccccc1c1cn2c(csc2n1)CN1CCOCC1
Chemical Name

4-methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(pyridin-3-yl)thiazole-5-carboxamide

1. Mercken EM, et al. Aging Cell. 2014, 13(5), 787-796.

Calculator

molnova catalog