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SRI-42127
CAS No. 2727872-68-4
SRI-42127( —— )
Catalog No. M36510 CAS No. 2727872-68-4
SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 88 | Get Quote |
|
| 5MG | 132 | Get Quote |
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| 10MG | 242 | Get Quote |
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| 25MG | 472 | Get Quote |
|
| 50MG | 670 | Get Quote |
|
| 100MG | 887 | Get Quote |
|
| 500MG | 1773 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSRI-42127
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NoteResearch use only, not for human use.
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Brief DescriptionSRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
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DescriptionSRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHuR
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Research Area——
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Indication——
Chemical Information
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CAS Number2727872-68-4
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Formula Weight348.4
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Molecular FormulaC19H20N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (143.51 mM; Ultrasonic (<60°C)
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SMILESN1=CC=2C=CC(=CC2N1)C3=CN=C4C=CC(=NN43)N(C)C5CCOCC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chellappan R, et al. SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation. Glia. 2022 Jan;70(1):155-172. ?
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