
SRD5A1-IN-1
CAS No. 2279077-93-7
SRD5A1-IN-1( —— )
Catalog No. M36063 CAS No. 2279077-93-7
SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 μM).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 147 | Get Quote |
![]() ![]() |
5MG | 227 | Get Quote |
![]() ![]() |
10MG | 330 | Get Quote |
![]() ![]() |
25MG | 517 | Get Quote |
![]() ![]() |
50MG | 716 | Get Quote |
![]() ![]() |
100MG | 888 | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameSRD5A1-IN-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionSRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 μM).
-
DescriptionSRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 μM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression.
-
In VitroWestern Blot Analysis Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 hResult:Showed a significant decrease in SRD5A1 protein expression at 1 and 2.5 μM at 24 h, whereas there were no significant changes in the level of SRD5A1 protein at 12 h.RT-PCR Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 h Result:Did not affect the mRNA expression of SRD5A1 at both incubation times.Cell Cytotoxicity Assay Cell Line:HaCaT Concentration:0.2, 0.5, 1, and 2.5 μM Incubation Time:24 h Result:Displayed no significant cytotoxicity (IC50: 29.99?±?8.69 μM).
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2279077-93-7
-
Formula Weight391.27
-
Molecular FormulaC17H11F6NO3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (255.58 mM; Ultrasonic )
-
SMILESN(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lin A C K, et al. Caffeic acid N-[3, 5-bis (trifluoromethyl) phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics. Scientific Reports, 2022, 12(1): 1-20.
molnova catalog



related products
-
Diquat dibromide
Diquat dibromide is a water-soluble herbicide that causes rapid and profound systemic toxicity.Diquat dibromide induces acute kidney injury with high lethality.3-Phosphoglyceraldehyde has been shown to be effective in the treatment of LPS-induced ALI.
-
Propargyl-PEG11-meth...
Propargyl-PEG11-methane is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
-
Butyrophenone
Butyrophenone is a chemical compound. Some of its derivatives are used to treat various psychiatric disorders.