SRD5A1-IN-1

CAS No. 2279077-93-7

SRD5A1-IN-1( —— )

Catalog No. M36063 CAS No. 2279077-93-7

SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 147 Get Quote
5MG 227 Get Quote
10MG 330 Get Quote
25MG 517 Get Quote
50MG 716 Get Quote
100MG 888 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    SRD5A1-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 μM).
  • Description
    SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 μM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression.
  • In Vitro
    Western Blot Analysis Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 hResult:Showed a significant decrease in SRD5A1 protein expression at 1 and 2.5 μM at 24 h, whereas there were no significant changes in the level of SRD5A1 protein at 12 h.RT-PCR Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 h Result:Did not affect the mRNA expression of SRD5A1 at both incubation times.Cell Cytotoxicity Assay Cell Line:HaCaT Concentration:0.2, 0.5, 1, and 2.5 μM Incubation Time:24 h Result:Displayed no significant cytotoxicity (IC50: 29.99?±?8.69 μM).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2279077-93-7
  • Formula Weight
    391.27
  • Molecular Formula
    C17H11F6NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (255.58 mM; Ultrasonic )
  • SMILES
    N(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lin A C K, et al. Caffeic acid N-[3, 5-bis (trifluoromethyl) phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics. Scientific Reports, 2022, 12(1): 1-20.
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