SR8278

CAS No. 1254944-66-5

SR8278 ( —— )

Catalog No. M21127 CAS No. 1254944-66-5

SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM) blocking activation of the receptor by the synthetic agonist GSK 4112.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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50MG 414 In Stock
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Biological Information

  • Product Name
    SR8278
  • Note
    Research use only not for human use.
  • Brief Description
    SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM) blocking activation of the receptor by the synthetic agonist GSK 4112.
  • Description
    SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM) blocking activation of the receptor by the synthetic agonist GSK 4112.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    REV-ERBα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1254944-66-5
  • Formula Weight
    361.48
  • Molecular Formula
    C18H19NO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10mg/ml(27.66mM)
  • SMILES
    CCOC(=O)C1Cc2ccccc2CN1C(=O)c1ccc(SC)s1
  • Chemical Name
    ethyl 2-{[5-(methylsulfanyl)thiophen-2-yl]carbonyl}-1234-tetrahydroisoquinoline-3-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kojetin D Wang Y Kamenecka T M et al. Identification of SR8278 a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB[J]. Acs Chemical Biology 2011 6(2):131-134.
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