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SR2211

CAS No. 1359164-11-6

SR2211( —— )

Catalog No. M33503 CAS No. 1359164-11-6

SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SR2211
  • Note
    Research use only, not for human use.
  • Brief Description
    SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).
  • Description
    SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
  • In Vitro
    The treatment of EL4 with SR2211 represses the IL-17 gene expression. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211. Treatment of EL-4 cells with SR2211 results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    ROR
  • Recptor
    ROR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1359164-11-6
  • Formula Weight
    527.48
  • Molecular Formula
    C26H24F7N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (189.58 mM; Ultrasonic )
  • SMILES
    OC(c1ccc(c(F)c1)-c1ccc(CN2CCN(Cc3ccncc3)CC2)cc1)(C(F)(F)F)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kumar N, et al. Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol. 2012 Apr 20;7(4):672-7.?
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