Cart
sales@molnova.com
SR-4835
CAS No. 2387704-62-1
SR-4835( —— )
Catalog No. M21578 CAS No. 2387704-62-1
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
|
| 5MG | 110 | In Stock |
|
| 10MG | 178 | In Stock |
|
| 25MG | 368 | In Stock |
|
| 50MG | 536 | In Stock |
|
| 100MG | 779 | In Stock |
|
| 500MG | 1593 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSR-4835
-
NoteResearch use only, not for human use.
-
Brief DescriptionSR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
-
DescriptionSR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM Kd=98 nM; CDK13: Kd=4.9 nM) which disables triple-negative breast cancer (TNBC) cells.
-
In VitroWestern Blot Analysis Cell Line:MDA-MB-231 cells Concentration:90 nM Incubation Time:0.5, 6, 24, 48 hours Result:Suppressed ATM and RAD51 protein levels.
-
In Vivo——
-
Synonyms——
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2387704-62-1
-
Formula Weight499.36
-
Molecular FormulaC21H20Cl2N10O
-
Purity>98% (HPLC)
-
SolubilityDMSO:5 mg/mL (10.01 mM; ultrasonic and warming and heat to 60°C)
-
SMILESCn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Quereda V et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell. 2019 Oct 8. pii: S1535-6108(19)30424-6.
molnova catalog
related products
-
AZD 5597
A highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM.
-
LY2835219
LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM, respectively.
-
Purvalanol A
A potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
