SR-3677

CAS No. 1072959-67-1

SR-3677( —— )

Catalog No. M23281 CAS No. 1072959-67-1

SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 38 In Stock
5MG 61 In Stock
10MG 91 In Stock
25MG 165 In Stock
50MG 302 In Stock
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Biological Information

  • Product Name
    SR-3677
  • Note
    Research use only, not for human use.
  • Brief Description
    SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
  • Description
    SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).(In Vitro):SR-3677 has an IC50 of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC50 value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677.(In Vivo): Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 μM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy|ROCK1|ROCK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1072959-67-1
  • Formula Weight
    408.45
  • Molecular Formula
    C22H24N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:40 mg/mL (97.93 mM)
  • SMILES
    CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.
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