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SR-3677
CAS No. 1072959-67-1
SR-3677( —— )
Catalog No. M23281 CAS No. 1072959-67-1
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 38 | In Stock |
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| 5MG | 61 | In Stock |
|
| 10MG | 91 | In Stock |
|
| 25MG | 165 | In Stock |
|
| 50MG | 302 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSR-3677
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NoteResearch use only, not for human use.
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Brief DescriptionSR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
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DescriptionSR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).(In Vitro):SR-3677 has an IC50 of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC50 value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677.(In Vivo): Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 μM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy|ROCK1|ROCK2
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Research Area——
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Indication——
Chemical Information
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CAS Number1072959-67-1
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Formula Weight408.45
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Molecular FormulaC22H24N4O4
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Purity>98% (HPLC)
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SolubilityDMSO:40 mg/mL (97.93 mM)
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SMILESCN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.
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