Cart
sales@molnova.com
SPDB
CAS No. 115088-06-7
SPDB( SPDB, SPDB disulfide heterobifunctional cross-linker )
Catalog No. M10531 CAS No. 115088-06-7
SPDB is a disulfide chemical linker for antibody-drug conjugates (ADCs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
|
| 5MG | 77 | In Stock |
|
| 10MG | 107 | In Stock |
|
| 50MG | 251 | In Stock |
|
| 100MG | 341 | In Stock |
|
| 200MG | 537 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSPDB
-
NoteResearch use only, not for human use.
-
Brief DescriptionSPDB is a disulfide chemical linker for antibody-drug conjugates (ADCs).
-
DescriptionSPDB is a disulfide chemical linker for antibody-drug conjugates (ADCs).
-
In Vitro——
-
In Vivo——
-
SynonymsSPDB, SPDB disulfide heterobifunctional cross-linker
-
PathwayAntibody Drug Conjugates (ADC)
-
TargetADCs Linker/Click Chemistry
-
RecptorOthers
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number115088-06-7
-
Formula Weight326.3913
-
Molecular FormulaC13H14N2O4S2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(ON1C(CCC1=O)=O)CCCSSC2=NC=CC=C2
-
Chemical NameButanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Cumber AJ, et al. Bioconjug Chem. 1992 Sep-Oct;3(5):397-401.
2. Erickson HK, et al. Cancer Res. 2006 Apr 15;66(8):4426-33.
3. Ikeda H, et al. Clin Cancer Res. 2009 Jun 15;15(12):4028-37.
4. Zhao RY, et al. J Med Chem. 2011 May 26;54(10):3606-23.
molnova catalog
related products
-
DSS Crosslinker
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters at both ends of an 8-atom (11.4 angstrom) spacer arm that are used to conjugate proteins.
-
DOTA-ADIBO
DOTA-ADIBO is a Click Chemistry intermidate used for antibody-drug conjugates.
-
N-Boc-4-hydroxy-L-pr...
N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction .
