Cart
sales@molnova.com
SPD304
CAS No. 869998-49-2
SPD304( —— )
Catalog No. M26461 CAS No. 869998-49-2
SPD304 is a selective TNF-α inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 binding to TNF-α.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 214 | Get Quote |
|
| 50MG | 834 | Get Quote |
|
| 100MG | 1251 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSPD304
-
NoteResearch use only, not for human use.
-
Brief DescriptionSPD304 is a selective TNF-α inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 binding to TNF-α.
-
DescriptionSPD304 is a selective TNF-α inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 binding to TNF-α.(In Vitro):SPD304 (2 μM) obviously rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold and p?RIP3 1.4?fold compared to GA alone and promotes caspase 8 activation .
-
In VitroSPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p?RIP3 1.4?fold compared to GA alone, and promotes caspase 8 activation.
-
In VivoSPD304 cannot be used in vivo due to its high toxicity.
-
Synonyms——
-
PathwayApoptosis
-
TargetTNF
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number869998-49-2
-
Formula Weight547.622
-
Molecular FormulaC32H32F3N3O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (45.65 mM)
-
SMILESCN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Khailova LS, Nazarov PA, Sumbatyan NV, Korshunova GA, Rokitskaya TI, Dedukhova VI, Antonenko YN, Skulachev VP. Uncoupling and Toxic Action of Alkyltriphenylphosphonium Cations on Mitochondria and the Bacterium Bacillus subtilis as a Function of Alkyl Chain Length. Biochemistry (Mosc). 2015 Dec;80(12):1589-97.
molnova catalog
related products
-
Adalimumab
Adalimumab anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
-
α-Humulene
α-Humulene is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production and COX-2 and iNOS expression.
-
Clematichinenoside A...
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.
