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Home - Products - Chromatin/Epigenetic - Histone Demethylase - SP2509

SP2509

CAS No. 1423715-09-6

SP2509 ( SP-2509 )

Catalog No. M11788 CAS No. 1423715-09-6

SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SP2509
  • Note
    Research use only, not for human use.
  • Brief Description
    SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM.
  • Description
    SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase; inhibits the colony growth of OCI-AML3 significantly more than of the other AML cell-types, induces more apoptosis of AML cells expressing mutant NPM1 than mixed-lineage leukemia fusion oncoproteins; significantly improves the survival of immune-depleted mice model of AML, SP2509 is synergistically lethal against cultured and primary AML blasts combined with panobinostat.
  • Synonyms
    SP-2509
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    LSD1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1423715-09-6
  • Formula Weight
    437.90
  • Molecular Formula
    C19H20ClN3O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2
  • Chemical Name
    Benzoic acid, 3-(4-morpholinylsulfonyl)-, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fiskus W, et al. Leukemia. 2014 Nov;28(11):2155-64.
2. Sonnemann J, et al. Br J Haematol. 2017 Dec 3. doi: 10.1111/bjh.14983.
3. Sehrawat A, et al. Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 201719168.
4. Khanal T, et al. Sci Rep. 2017 Sep 6;7(1):10662.
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