SP-13786 ( UAMC-1110 )

Catalog No. M21138 CAS No. 1448440-52-5

SP-13786 is an inhibitor of fibroblast activation protein (FAP) (IC50 : 3.2 nM); also inhibits prolyl oligopeptidase (PREP) ( IC50 : 1.8 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

SP-13786
Note

Research use only not for human use.
Brief Description

SP-13786 is an inhibitor of fibroblast activation protein (FAP) (IC50 : 3.2 nM); also inhibits prolyl oligopeptidase (PREP) ( IC50 : 1.8 μM).
Description

SP-13786 is an inhibitor of fibroblast activation protein (FAP) (IC50 : 3.2 nM); also inhibits prolyl oligopeptidase (PREP) ( IC50 : 1.8 μM).
Synonyms

UAMC-1110
Pathway

Others
Target

Other Targets
Recptor

FAP
Research Area

——
Indication

——

Chemical Information

CAS Number

1448440-52-5
Formula Weight

344.32
Molecular Formula

C17H14F2N4O2
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (290.43 mM; Need ultrasonic)
SMILES

N#CC1CC(F)(F)CN1C(=O)CNC(=O)c1ccnc2ccccc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Jansen K Heirbaut L Verkerk R et al. Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)[J]. Journal of Medicinal Chemistry 2014 57(7):3053-3074.

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