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SP-13786

CAS No. 1448440-52-5

SP-13786( UAMC-1110 )

Catalog No. M21138 CAS No. 1448440-52-5

SP-13786 is an inhibitor of fibroblast activation protein (FAP) (IC50 : 3.2 nM); also inhibits prolyl oligopeptidase (PREP) ( IC50 : 1.8 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SP-13786
  • Note
    Research use only, not for human use.
  • Brief Description
    SP-13786 is an inhibitor of fibroblast activation protein (FAP) (IC50 : 3.2 nM); also inhibits prolyl oligopeptidase (PREP) ( IC50 : 1.8 μM).
  • Description
    SP-13786 is an inhibitor of fibroblast activation protein (FAP) (IC50 : 3.2 nM); also inhibits prolyl oligopeptidase (PREP) ( IC50 : 1.8 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    UAMC-1110
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FAP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1448440-52-5
  • Formula Weight
    344.32
  • Molecular Formula
    C17H14F2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (290.43 mM; Need ultrasonic)
  • SMILES
    N#CC1CC(F)(F)CN1C(=O)CNC(=O)c1ccnc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jansen K Heirbaut L Verkerk R et al. Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)[J]. Journal of Medicinal Chemistry 2014 57(7):3053-3074.
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