SNG-1153 ( SNG 1153;SNG1153 )

Catalog No. M11901 CAS No. 1446712-19-1

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Product Name

SNG-1153
Note

Research use only, not for human use.
Brief Description

A derivate of icaritin that inhibits the growth of lung CSCs.
Description

A derivate of icaritin that inhibits the growth of lung CSCs; inhibits the tumorsphere formation and decreases CD133-positive (lung CSC marker) cancer cells, attenuates tumor formation in NOD/SCID mice; induces β-catenin phosphorylation and down-regulated β-catenin; targets abnormal ERα36 activity, inhibits cell growth and induces apoptosis of BCR-ABL+ leukemic cells, particularly BCR-ABL-T315I mutant cells; effectively eliminates infiltrated BCR-ABL+ blast cells and enhances survival of mice combined with dasatinib.Breast Cancer Preclinical
Synonyms

SNG 1153;SNG1153
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

Estrogen Receptor/ERR
Research Area

Cancer
Indication

Breast Cancer

CAS Number

1446712-19-1
Formula Weight

406.35
Molecular Formula

C21H17F3O5
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

O=C1C(O)=C(C2=CC=C(C(F)(F)F)C=C2)OC3=C1C(O)=CC(O)=C3C/C=C(C)\C
Chemical Name

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8-(3-methyl-2-buten-1-yl)-2-[4-(trifluoromethyl)phenyl]-

1. Liu S, et al. Oncotarget. 2016 Jul 19;7(29):45158-45170.
2. Chen M, et al. Oncotarget. 2017 Jul 4;8(27):43662-43677.

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