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SMS2-IN-2
CAS No. 2241838-28-6
SMS2-IN-2( SMS2 inhibitors )
Catalog No. M20666 CAS No. 2241838-28-6
SMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 152 | In Stock |
|
| 5MG | 259 | In Stock |
|
| 10MG | 404 | In Stock |
|
| 25MG | 665 | In Stock |
|
| 50MG | 888 | In Stock |
|
| 100MG | 1251 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSMS2-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionSMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
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DescriptionSMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
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In Vitro——
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In VivoSMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice. Animal Model:Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)Dosage:20, 50 mg/kg/day Administration:P.O. daily for 6 weeks Result:Significantly reduced IL-6 and insulin levels.
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SynonymsSMS2 inhibitors
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PathwayOthers
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TargetOther Targets
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RecptorSMS2
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Research Area——
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Indication——
Chemical Information
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CAS Number2241838-28-6
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Formula Weight369.78
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Molecular FormulaC19H13ClFN3O2
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (676.08 mM)
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SMILESFc1ccc(Cl)c(COc2cccc3onc(Nc4cccnc4)c23)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mo M Yang J Jiang XCet al.Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice[J].J Med Chem. 2018 Sep 27;61(18):8241-8254.?
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