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SMS2-IN-2

CAS No. 2241838-28-6

SMS2-IN-2 ( SMS2 inhibitors )

Catalog No. M20666 CAS No. 2241838-28-6

SMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SMS2-IN-2
  • Note
    Research use only not for human use.
  • Brief Description
    SMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
  • Description
    SMS2-IN-2 is a potent selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50s of 100 and 56 μM for SMS2 and SMS1 respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
  • Synonyms
    SMS2 inhibitors
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SMS2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2241838-28-6
  • Formula Weight
    369.78
  • Molecular Formula
    C19H13ClFN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (676.08 mM)
  • SMILES
    Fc1ccc(Cl)c(COc2cccc3onc(Nc4cccnc4)c23)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mo M Yang J Jiang XCet al.Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice[J].J Med Chem. 2018 Sep 27;61(18):8241-8254.?
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