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SMS2-IN-1

CAS No. 2098890-15-2

SMS2-IN-1( —— )

Catalog No. M26453 CAS No. 2098890-15-2

SMS2-IN-1 is a highly selective inhibitor of sphingomyelin synthase 2 (SMS2)(IC50 of 6.5 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SMS2-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SMS2-IN-1 is a highly selective inhibitor of sphingomyelin synthase 2 (SMS2)(IC50 of 6.5 nM).
  • Description
    SMS2-IN-1 is a highly selective inhibitor of sphingomyelin synthase 2 (SMS2)(IC50 of 6.5 nM).(In Vitro):SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 with IC50 of 1000 nM.
  • In Vitro
    AS/MS binding experiments are conducted using these SMS2-mutant membrane fractions, SMS2-IN-1 (compound 2) binds to the S217A, H272A, and D276A mutants. S227 and H229 are pivotal amino acid residues for the binding of SMS2-IN-1 to SMS2.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    RXR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2098890-15-2
  • Formula Weight
    681.676
  • Molecular Formula
    C34H37F6N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 27.78 mg/mL (40.75 mM)
  • SMILES
    CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)c1c(OCCCC2CCN(CC2)C(=O)OC2(C)CC2)c2ccccc2n(C)c1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bradley SM, Chan PS, Spertus JA, Kennedy KF, Douglas PS, Patel MR, Anderson HV, Ting HH, Rumsfeld JS, Nallamothu BK. Hospital percutaneous coronary intervention appropriateness and in-hospital procedural outcomes: insights from the NCDR. Circ Cardiovasc Qual Outcomes. 2012 May;5(3):290-7.
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