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SMIFH2

CAS No. 340316-62-3

SMIFH2( —— )

Catalog No. M27714 CAS No. 340316-62-3

SMIFH2 is formin homology 2 (FH2) domains inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 36 In Stock
5MG 58 In Stock
10MG 87 In Stock
25MG 178 In Stock
50MG 356 In Stock
100MG 528 In Stock
500MG 1035 In Stock
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Biological Information

  • Product Name
    SMIFH2
  • Note
    Research use only, not for human use.
  • Brief Description
    SMIFH2 is formin homology 2 (FH2) domains inhibitor.
  • Description
    SMIFH2 is formin homology 2 (FH2) domains inhibitor.
  • In Vitro
    SMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells. SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner.SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton. Western Blot Analysis Cell Line:293T, A375, U2OS, and MDA-MB-231 cells Concentration:25 μM Incubation Time:5 hours for 293T, U2OS, MDA-MB-231 cells; 2.5 hours for A375 cells Result:Downregulated mDia2, p53 and p300 protein levels.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    mGluR5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    340316-62-3
  • Formula Weight
    377.21
  • Molecular Formula
    C15H9BrN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (331.38 mM)
  • SMILES
    Brc1cccc(c1)N1C(=S)NC(=O)\C(=C/c2ccco2)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Keck TM, et al. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol.
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