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SMIFH2
CAS No. 340316-62-3
SMIFH2( —— )
Catalog No. M27714 CAS No. 340316-62-3
SMIFH2 is formin homology 2 (FH2) domains inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | In Stock |
|
| 5MG | 58 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 356 | In Stock |
|
| 100MG | 528 | In Stock |
|
| 500MG | 1035 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSMIFH2
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NoteResearch use only, not for human use.
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Brief DescriptionSMIFH2 is formin homology 2 (FH2) domains inhibitor.
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DescriptionSMIFH2 is formin homology 2 (FH2) domains inhibitor.
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In VitroSMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells. SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner.SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton. Western Blot Analysis Cell Line:293T, A375, U2OS, and MDA-MB-231 cells Concentration:25 μM Incubation Time:5 hours for 293T, U2OS, MDA-MB-231 cells; 2.5 hours for A375 cells Result:Downregulated mDia2, p53 and p300 protein levels.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptormGluR5
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Research Area——
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Indication——
Chemical Information
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CAS Number340316-62-3
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Formula Weight377.21
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Molecular FormulaC15H9BrN2O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (331.38 mM)
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SMILESBrc1cccc(c1)N1C(=S)NC(=O)\C(=C/c2ccco2)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Keck TM, et al. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol.
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