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SMI-16a

CAS No. 587852-28-6

SMI-16a( Pim1/2 Inhibitor IV | PIM1/2 Kinase Inhibitor VI )

Catalog No. M17550 CAS No. 587852-28-6

PIM1/2 Kinase Inhibitor VI, a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SMI-16a
  • Note
    Research use only, not for human use.
  • Brief Description
    PIM1/2 Kinase Inhibitor VI, a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM).
  • Description
    SMI-16a, also known as Pim1/2 Inhibitor IV, is a potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Pim1/2 Inhibitor IV | PIM1/2 Kinase Inhibitor VI
  • Pathway
    GPCR/G Protein
  • Target
    GPCR19
  • Recptor
    Pim1| Pim2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    587852-28-6
  • Formula Weight
    263.31
  • Molecular Formula
    C13H13NO3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 150 mg/mL; 569.67 mM
  • SMILES
    CCCOC1=CC=C(C=C1)/C=C\2/C(=O)NC(=O)S2
  • Chemical Name
    (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xia Z., et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52(1):74-86.
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