SL-327 ( SL327; SL 327; SL-327 )

Catalog No. M18397 CAS No. 305350-87-2

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Product Name

SL-327
Note

Research use only, not for human use.
Brief Description

SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
Description

SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization.
Synonyms

SL327; SL 327; SL-327
Pathway

Others
Target

Other Targets
Recptor

AP-1; MEK1; MEK2
Research Area

Cancer
Indication

——

CAS Number

305350-87-2
Formula Weight

335.35
Molecular Formula

C16H12F3N3S
Purity

98%
Solubility

DMSO : 68 mg/mL 202.77 mM; Ethanol : 0.1 mg/mL 0.30 mM;
SMILES

c1ccc(c(c1)C(=C(N)Sc1ccc(cc1)N)C#N)C(F)(F)F
Chemical Name

(E)-3-amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile

1. Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.

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