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SL-327
CAS No. 305350-87-2
SL-327( SL327 | SL 327 | SL-327 )
Catalog No. M18397 CAS No. 305350-87-2
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
Purity : >98% (HPLC)
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Size | Price / USD | Stock | Quantity |
5MG | 43 | In Stock |
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10MG | 61 | In Stock |
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50MG | 156 | In Stock |
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100MG | Get Quote | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameSL-327
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NoteResearch use only, not for human use.
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Brief DescriptionSL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
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DescriptionSL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization.
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In Vitro——
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In Vivo——
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SynonymsSL327 | SL 327 | SL-327
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PathwayOthers
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TargetOther Targets
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RecptorAP-1| MEK1| MEK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number305350-87-2
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Formula Weight335.35
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Molecular FormulaC16H12F3N3S
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Purity>98% (HPLC)
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SolubilityDMSO : 68 mg/mL 202.77 mM; Ethanol : 0.1 mg/mL 0.30 mM
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SMILESc1ccc(c(c1)C(=C(N)Sc1ccc(cc1)N)C#N)C(F)(F)F
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Chemical Name(E)-3-amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.
molnova catalog
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