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SKI-178

CAS No. 1259484-97-3

SKI-178 ( —— )

Catalog No. M23431 CAS No. 1259484-97-3

SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 59 In Stock
10MG 104 In Stock
25MG 203 In Stock
50MG 327 In Stock
100MG 492 In Stock
500MG 1053 In Stock
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Biological Information

  • Product Name
    SKI-178
  • Note
    Research use only, not for human use.
  • Brief Description
    SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?
  • Description
    SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade.?The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.?
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis;SphK1;SphK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1259484-97-3
  • Formula Weight
    394.4
  • Molecular Formula
    C21H22N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL?(126.77 mM;?Need ultrasonic)
  • SMILES
    O=C(C1=CC(C2=CC=C(OC)C=C2)=NN1)N/N=C(C3=CC=C(OC)C(OC)=C3)\C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hengst JA, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Transl Med. 2017;3(4):109-121.
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