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SKI-178
CAS No. 1259484-97-3
SKI-178 ( —— )
Catalog No. M23431 CAS No. 1259484-97-3
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 37 | In Stock |
|
| 5MG | 59 | In Stock |
|
| 10MG | 104 | In Stock |
|
| 25MG | 203 | In Stock |
|
| 50MG | 327 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 500MG | 1053 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSKI-178
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NoteResearch use only, not for human use.
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Brief DescriptionSKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?
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DescriptionSKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM.?It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade.?The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.?
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis;SphK1;SphK2
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Research Area——
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Indication——
Chemical Information
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CAS Number1259484-97-3
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Formula Weight394.4
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Molecular FormulaC21H22N4O4
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL?(126.77 mM;?Need ultrasonic)
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SMILESO=C(C1=CC(C2=CC=C(OC)C=C2)=NN1)N/N=C(C3=CC=C(OC)C(OC)=C3)\C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hengst JA, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Transl Med. 2017;3(4):109-121.
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