SKA31

Research use only, not for human use.

SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50s: 260 2900 2900 nM for KCa3.1 KCa2.1 and KCa2.2 respectively).

SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50s: 260 2900 2900 nM for KCa3.1 KCa2.1 and KCa2.2 respectively).

Cell Viability Assay Cell Line:HCT-116 cells, HCT-8 cells Concentration:Incubation Time:24?hours Result:Reduced cell viability with IC50s of 5.3 μM , 46.9 μM in HCT-116 and HCT-8, respectively.Cell Proliferation AssayCell Line:HCT-116 cells Concentration:5.3 μM Incubation Time:0-96 hours Result:Reduced HCT-116 cells proliferation when added at time zero at IC50S value.Apoptosis Analysis Cell Line:HCT-116 cells, HCT-8 cells Concentration:5 μM (HCT-116 cells), 45 μM (HCT-8 cells)Incubation Time:24?hours Result:Triggered apoptosis in HCT-116 cells, and the effect was smaller in HCT-8 cells.Cell Cycle Analysis Cell Line:HCT-116 cells, HCT-8 cells Concentration:5 μM (HCT-116), 45 μM (HCT-8)Incubation Time:24?hours Result:Increased the percentage of cells in G0/G1 phase in HCT-116 and HCT-8 cell lines.Western Blot Analysis Cell Line:HCT-116 cells Concentration:Incubation Time:24?hours Result:Further activated Caspase 3 and reduced Akt phosphorylation when co-treatment with CDDP in HCT-116 cells.

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SKA 31 | SKA-31 | Naphtho[12-d]thiazol-2-ylamine

Cell Cycle/DNA Damage

Potassium Channel

KCa3.1 channel

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40172-65-4

200.26

C11H8N2S

>98% (HPLC)

DMSO: 30 mg/mL (150 mM)

Nc1nc2c(ccc3ccccc23)s1

Naphtho[12-d]thiazol-2-ylamine

(-20℃)

With Ice Pack

≥ 2 years