SK33

Research use only, not for human use.

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.(In Vitro):SK33 has a significantly potent activity (IC50:0.2 μM) in LNCaPAR+?cells. SK33 decreases cells enter S-phase in LNCaP cells. In LNCaP/BicR cells, increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth(IC50?: 5 μM for SK33).(In Vivo):AR transcriptional activity inhibited by SK33 after 50 mg/kg treatment for 24 hours.

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Endocrinology/Hormones

Androgen Receptor (AR)

5-HT3; α7 nAChR

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1928724-23-5

500.3

C20H13F9N2O3

>98% (HPLC)

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CC(O)(COc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years