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SK1-IN-1

CAS No. 1218816-71-7

SK1-IN-1( —— )

Catalog No. M33126 CAS No. 1218816-71-7

SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SK1-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.
  • Description
    SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM.
  • In Vitro
    ——
  • In Vivo
    SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    S1P Receptor
  • Recptor
    S1P Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1218816-71-7
  • Formula Weight
    398.5
  • Molecular Formula
    C22H30N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (250.94 mM)
  • SMILES
    C(CC1CCCC1)C2=NC(=NO2)C3=CC=C([C@@H](NC(=O)[C@@H]4[C@@H](O)CCN4)C)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4.?
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