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SJ6986
CAS No. 2765625-93-0
SJ6986( —— )
Catalog No. M28351 CAS No. 2765625-93-0
SJ6986 is a chemical probe for studying the role of GSPT1/2 in vitro and in vivo. SJ6986 supports the utility of a diverse library of CRBN binders in the pursuit of targeting undruggable oncoproteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | Get Quote |
|
| 10MG | 70 | Get Quote |
|
| 50MG | 231 | Get Quote |
|
| 100MG | 357 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSJ6986
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NoteResearch use only, not for human use.
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Brief DescriptionSJ6986 is a chemical probe for studying the role of GSPT1/2 in vitro and in vivo. SJ6986 supports the utility of a diverse library of CRBN binders in the pursuit of targeting undruggable oncoproteins.
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DescriptionSJ6986 is a chemical probe for studying the role of GSPT1/2 in vitro and in vivo. SJ6986 supports the utility of a diverse library of CRBN binders in the pursuit of targeting undruggable oncoproteins.
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In VitroSJ6986 exhibits EC50 values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively. Cell Proliferation Assay Cell Line:MV4-11 cells.Concentration:0-100 μM.Incubation Time:3 days.Result:Exhibited EC50 of 1.5 nM.Western Blot Analysis Cell Line:MV4-11 cells.Concentration:0-10 μM.Incubation Time:4 and 24 h.Result:Dose- and time-dependently decreased the protein levels of GSPT1.
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In VivoSJ6986 exhibits t1/2 of 3.44 h by iv injection of 3 mg/kg and tmax of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorABCG2
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Research Area——
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Indication——
Chemical Information
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CAS Number2765625-93-0
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Formula Weight497.4
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Molecular FormulaC20H14F3N3O7S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (201.05 mM)
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SMILESO=C(N1)CCC(N2C(C(C=C(NS(C3=C(OC(F)(F)F)C=CC=C3)(=O)=O)C=C4)=C4C2=O)=O)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.You Q, et al. Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma. J Agric Food Chem. 2021 Nov 3;69(43):12705-12716.
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