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SJ572403

CAS No. 19970-45-7

SJ572403( SJ403 )

Catalog No. M26819 CAS No. 19970-45-7

SJ572403 is an inhibitor of disordered protein p27.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SJ572403
  • Note
    Research use only, not for human use.
  • Brief Description
    SJ572403 is an inhibitor of disordered protein p27.
  • Description
    SJ572403 is an inhibitor of disordered protein p27.(In Vitro):SJ572403 (10 μM-3 mM) replaces p27-D2 on Cdk2/cyclin A and partially restores Cdk2 kinase activity. SJ572403 (0-3 mM) modulates Cdk regulation of p27.
  • In Vitro
    SJ572403 (SJ403) (3 mM) shows specific interactions with specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM.SJ572403 (0-3 mM) modulates p27's Cdk regulatory.SJ572403 (10 μM-3 mM) displaces p27-D2 from Cdk2/cyclin A and partially restores Cdk2 kinase activity.
  • In Vivo
    ——
  • Synonyms
    SJ403
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HIV-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    19970-45-7
  • Formula Weight
    275.312
  • Molecular Formula
    C13H17N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 13.89 mg/mL (50.45 mM)
  • SMILES
    CCn1c(C)c(C)n2c1nc1n(C)c(=O)n(C)c(=O)c21
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kortagere S, et al. Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication. J Chem Inf Model. 2014 Nov 24;54(11):3080-90.
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