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Home - Products - Microbiology/Virology - Parasite - SJ-733

SJ-733

CAS No. 1424799-20-1

SJ-733 ( +)-SJ733;SJ000557733;SJ-557733 )

Catalog No. M11792 CAS No. 1424799-20-1

SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SJ-733
  • Note
    Research use only, not for human use.
  • Brief Description
    SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite.
  • Description
    SJ-733 (SJ000557733;SJ-557733) is an anti-malarial compound that targets ATP4, a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite; displays high potency in vitro against all tested strains of P. falciparum with EC50 of 10-60 nM; kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo; high oral bioavailabilityParasite Infection Phase 1 Clinical
  • Synonyms
    +)-SJ733;SJ000557733;SJ-557733
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    Infection
  • Indication
    Parasite Infection

Chemical Information

  • CAS Number
    1424799-20-1
  • Formula Weight
    468.41
  • Molecular Formula
    C24H16F4N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL 106.75 mM
  • SMILES
    O=C([C@@H](C1=C2C=CC=C1)[C@@H](C3=CC=CN=C3)N(CC(F)(F)F)C2=O)NC4=CC=C(F)C(C#N)=C4
  • Chemical Name
    (3S,4S)-N-(3-Cyano-4-fluorophenyl)-1-oxo-3-(3-pyridinyl)-2-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydro-4-isoquinolinecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiménez-Díaz MB, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62.
2. Crawford ED, et al. PLoS One. 2017 May 22;12(5):e0178163.
3. Mogollon CM, et al. PLoS One. 2016 Dec 20;11(12):e0168362.
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