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SIB-1757
CAS No. 31993-01-8
SIB-1757( 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 )
Catalog No. M21962 CAS No. 31993-01-8
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM),SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
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| 5MG | 110 | In Stock |
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| 10MG | 165 | In Stock |
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| 25MG | 295 | In Stock |
|
| 50MG | 430 | In Stock |
|
| 100MG | 597 | In Stock |
|
| 500MG | 1233 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSIB-1757
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NoteResearch use only, not for human use.
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Brief DescriptionSIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM),SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?
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DescriptionSIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM).SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route.
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In Vitro——
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In Vivo——
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Synonyms6-methyl-2-[(E)-phenyldiazenyl]pyridin-3
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PathwayNeuroscience
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TargetGluR
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RecptormGluR5
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Research Area——
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Indication——
Chemical Information
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CAS Number31993-01-8
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Formula Weight213.24
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Molecular FormulaC12H11N3O
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Purity>98% (HPLC)
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SolubilityDMSO:17 mg/ml(79.72 mM)
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SMILESCc1ccc(O)c(n1)\N=N\c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dogrul A , Ossipov M H , Lai J , et al. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats[J]. 2000, 292(2):0-118.2. Varney M A A , Cosford N D P , Jachec C , et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5[J]. Journal of Pharmacology & Experimental Therapeutics, 1999, 290(1):170-181.
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