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SHMT-IN-2
CAS No. 2102681-49-0
SHMT-IN-2( —— )
Catalog No. M35638 CAS No. 2102681-49-0
SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 112 | Get Quote |
|
| 5MG | 169 | Get Quote |
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| 10MG | 275 | Get Quote |
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| 25MG | 532 | Get Quote |
|
| 50MG | 854 | Get Quote |
|
| 100MG | 1125 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSHMT-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionSHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.
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DescriptionSHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas.
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In VitroSHMT-IN-2 (compound 2) can inhibit cell growth with cellular IC50 values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 (30 μM) shows the growth sensitivity with the median IC50 was 4 μM to a panel of nearly 300 human cancer cell lines (with IC50 values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2102681-49-0
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Formula Weight431.45
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Molecular FormulaC22H24F3N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (231.78 mM; Ultrasonic )
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SMILESCC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.?
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