SHMT-IN-2

CAS No. 2102681-49-0

SHMT-IN-2( —— )

Catalog No. M35638 CAS No. 2102681-49-0

SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 112 Get Quote
5MG 169 Get Quote
10MG 275 Get Quote
25MG 532 Get Quote
50MG 854 Get Quote
100MG 1125 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    SHMT-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.
  • Description
    SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas.
  • In Vitro
    SHMT-IN-2 (compound 2) can inhibit cell growth with cellular IC50 values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 (30 μM) shows the growth sensitivity with the median IC50 was 4 μM to a panel of nearly 300 human cancer cell lines (with IC50 values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2102681-49-0
  • Formula Weight
    431.45
  • Molecular Formula
    C22H24F3N5O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (231.78 mM; Ultrasonic )
  • SMILES
    CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.?
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