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SGN-2FF

CAS No. 2089647-47-0

SGN-2FF ( —— )

Catalog No. M26438 CAS No. 2089647-47-0

SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SGN-2FF
  • Note
    Research use only, not for human use.
  • Brief Description
    SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.
  • Description
    SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.(In Vitro):SGN-2FF is a fucosylation inhibitor, SGN-2FF inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of fucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.(In Vivo):In multiple mouse tumor models, SGN-2FF exhibits antitumor activity. SGN-2FF shows substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Telomerase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2089647-47-0
  • Formula Weight
    166.1
  • Molecular Formula
    C6H11FO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@@H]1OC(O)[C@@H](F)[C@H](O)[C@@H]1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Quan Wang J, et al. Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1199-1211.
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