SGC-2085 ( SGC2085;SGC 2085 )

Catalog No. M12811 CAS No. 1821908-48-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SGC-2085
Note

Research use only, not for human use.
Brief Description

SGC-2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM.
Description

SGC-2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM); also shows complete selectivity against a panel of 21 human protein methyltransferases.
Synonyms

SGC2085;SGC 2085
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

CARM1
Research Area

Cancer
Indication

——

CAS Number

1821908-48-8
Formula Weight

312.41
Molecular Formula

C19H24N2O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

CC1=CC(=CC(=C1)OC2=C(C=C(C=C2)CNC(=O)C(C)N)C)C
Chemical Name

Propanamide, 2-amino-N-[[4-(3,5-dimethylphenoxy)-3-methylphenyl]methyl]-, (2S)-

1. Ferreira de Freitas R, et al. J Med Chem. 2016 Jul 28;59(14):6838-47.

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