
SEA-0400
CAS No. 223104-29-8
SEA-0400( SEA0400 | SEA-0400 | SEA 0400 )
Catalog No. M17444 CAS No. 223104-29-8
SEA0400 is a selective inhibitor of the Na+/Ca2+?exchanger.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 41 | In Stock |
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5MG | 67 | In Stock |
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10MG | 120 | In Stock |
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25MG | 219 | In Stock |
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50MG | 357 | In Stock |
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100MG | 537 | In Stock |
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500MG | 1188 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameSEA-0400
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NoteResearch use only, not for human use.
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Brief DescriptionSEA0400 is a selective inhibitor of the Na+/Ca2+?exchanger.
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DescriptionSEA0400 is a Na+/Ca2+ exchanger 1 inhibitor. SEA0400 prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. SEA0400 reduces calcium overload induced by ischemia and reperfusion in mouse ventricular myocytes. SEA0400 attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. SEA0400, preserves cardiac function and high-energy phosphates against ischemia/reperfusion injury.
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In VitroSEA0400 inhibits Na+-dependent 45Ca2+ uptake in cultured neurons, astrocytes, and microglia. IC50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca2+-dependent manner.
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In VivoSEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.
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SynonymsSEA0400 | SEA-0400 | SEA 0400
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PathwayOthers
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TargetOther Targets
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RecptorNCX
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number223104-29-8
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Formula Weight371.38
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Molecular FormulaC21H19F2NO3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 32 mg/mL; 86.17 mM
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SMILESCCOc1cc(c(cc1)Oc1ccc(cc1)OCc1c(ccc(c1)F)F)N
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Chemical Name2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Matsuda, T., et al. J.Pharmacol.Exp.Ther. 2001, 298(1), 249-256.
molnova catalog



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