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SCYX-7158

CAS No. 1266084-51-8

SCYX-7158 ( AN-5568;SCYX 7158;AN 5568;Acoziborole )

Catalog No. M11117 CAS No. 1266084-51-8

SCYX-7158 (AN-5568, Acoziborole) is an orally-active, CNS permeable benzoxaborole antiprotozoal agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCYX-7158
  • Note
    Research use only, not for human use.
  • Brief Description
    SCYX-7158 (AN-5568, Acoziborole) is an orally-active, CNS permeable benzoxaborole antiprotozoal agent.
  • Description
    SCYX-7158 (AN-5568, Acoziborole) is an orally-active, CNS permeable benzoxaborole antiprotozoal agent; is active in vitro against relevant strains of Trypanosoma brucei, including T. b. rhodesiense and T. b. gambiense; is efficacious in both stage 1 and stage 2 murine HAT models and has good physicochemical and ADMET properties for the treatment of stage 2 human African trypanosomiasis.Parasite Infection Phase 3 Clinical
  • Synonyms
    AN-5568;SCYX 7158;AN 5568;Acoziborole
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    Infection
  • Indication
    Parasite Infection

Chemical Information

  • CAS Number
    1266084-51-8
  • Formula Weight
    367.10
  • Molecular Formula
    C17H14BF4NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 340.51 mM
  • SMILES
    FC1=CC(C(F)(F)F)=C(C(NC2=CC=C(C(C)(C)OB3O)C3=C2)=O)C=C1
  • Chemical Name
    4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-(trifluoromethyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jacobs RT, et al. PLoS Negl Trop Dis. 2011 Jun;5(6):e1151.
2. Jacobs RT, et al. Future Med Chem. 2011 Aug;3(10):1259-78.
3. Wring S, et al. Parasitology. 2014 Jan;141(1):104-18.
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