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SCH-772984
CAS No. 942183-80-4
SCH-772984 ( SCH 772984;SCH772984 )
Catalog No. M16741 CAS No. 942183-80-4
A novel potent and selective inhibitor of ERK1/ERK2 with IC50 of 4 nM/1 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 63 | In Stock |
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| 5MG | 90 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 276 | In Stock |
|
| 50MG | 414 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSCH-772984
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent and selective inhibitor of ERK1/ERK2 with IC50 of 4 nM/1 nM, respectively.
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DescriptionA novel potent and selective inhibitor of ERK1/ERK2 with IC50 of 4 nM/1 nM, respectively; is highly selective, with only seven kinases of 300 showing >50% inhibition at 1 uM; prevents MEK-mediated ERK phosphorylation, reduces pCRAF S289/S296/S301 phosphorylation; has nanomolar cellular potency in tumor cells with mutations in BRAF, NRAS, or KRAS and induces tumor regressions in xenograft models.Colon Cancer Phase 1 Clinical
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SynonymsSCH 772984;SCH772984
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PathwayMAPK/ERK Signaling
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TargetERK
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RecptorERK1;ERK2;MEK1
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Research AreaCancer
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IndicationColon Cancer
Chemical Information
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CAS Number942183-80-4
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Formula Weight587.67
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Molecular FormulaC33H33N9O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 51 mg/mL
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SMILESO=C([C@H]1CN(CC(N2CCN(C3=CC=C(C4=NC=CC=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=NC=C7)C=C5
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Chemical Name3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-, (3R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Morris EJ, et al. Cancer Discov. 2013 Jul;3(7):742-50.
2. Wong DJ, et al. Mol Cancer. 2014 Aug 20;13:194.
3. Chaikuad A, et al. Nat Chem Biol. 2014 Oct;10(10):853-60.
2. Wong DJ, et al. Mol Cancer. 2014 Aug 20;13:194.
3. Chaikuad A, et al. Nat Chem Biol. 2014 Oct;10(10):853-60.
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