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Home - Products - Apoptosis - Adenosine Receptor - SCH-58261

SCH-58261

CAS No. 160098-96-4

SCH-58261( SCH 58261 | SCH58261 )

Catalog No. M12299 CAS No. 160098-96-4

SCH-58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCH-58261
  • Note
    Research use only, not for human use.
  • Brief Description
    SCH-58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively.
  • Description
    SCH-58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively; displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively; reverses reperfusion injury (IR) increased hippocampal Glu, GABA, glycine and aspartate, MPO, TNF-α, nitric oxide, and PGE in Male Wistar rats.
  • In Vitro
    Cell Viability Assay Cell Line:H1975 cells Concentration:10 nM-10 μM Incubation Time:7 days Result:Produced a concentration-dependent decrease in H1975 cell growth.Cell Proliferation Assay Cell Line:CAF cells Concentration:25 μM Incubation Time:72 hours Result:Inhibit the growth of CAF1 and CAF2 cells.
  • In Vivo
    Animal Model: 4?6 weeks old athymic nude mice (NCI) with PC9 cells xenograftDosage:2 mg/kg Administration:Intraperitoneal injection; daily; for 20 days Result:Decreased tumor growth.
  • Synonyms
    SCH 58261 | SCH58261
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    A2A(bovine)|A2A(rat)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    160098-96-4
  • Formula Weight
    345.358
  • Molecular Formula
    C18H15N7O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 34 mg/mL
  • SMILES
    NC1=NC(N(CCC2=CC=CC=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14
  • Chemical Name
    7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zocchi C, et al. J Pharmacol Exp Ther. 1996 Feb;276(2):398-404. 2. Beavis PA, et al. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14711-6. 3. Mohamed RA, et al. Neurochem Res. 2012 Mar;37(3):538-47.
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