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SCH-546738
CAS No. 906805-42-3
SCH-546738( SCH546738 )
Catalog No. M16517 CAS No. 906805-42-3
SCH-546738 (SCH546738) is a potent, selective and non-competitive CXCR3 antagonist with binding Ki of 0.4 nM for human CXCR3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 239 | In Stock |
|
| 50MG | 999 | In Stock |
|
| 100MG | 1404 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSCH-546738
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NoteResearch use only, not for human use.
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Brief DescriptionSCH-546738 (SCH546738) is a potent, selective and non-competitive CXCR3 antagonist with binding Ki of 0.4 nM for human CXCR3.
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DescriptionSCH-546738 (SCH546738) is a potent, selective and non-competitive CXCR3 antagonist with binding Ki of 0.4 nM for human CXCR3; displaces radiolabeled CXCL10 and CXCL11 from human CXCR3 with IC50 of 0.8-2 nM, potently and specifically inhibits CXCR3-mediated chemotaxis in human activated T cells with IC90 of 10 nM; attenuates the disease development in mouse collagen-induced arthritis model.
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In Vitro——
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In Vivo——
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SynonymsSCH546738
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number906805-42-3
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Formula Weight492.4445
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Molecular FormulaC23H31Cl2N7O
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Purity>98% (HPLC)
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SolubilityDMSO: 4.5 mg/mL (Need ultrasonic)
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SMILESO=C(C1=NC(Cl)=C(N2C[C@H](CC)N(C3CCN(CC4=CC=C(Cl)C=C4)CC3)CC2)N=C1N)N
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Chemical Name2-Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jenh CH, et al. BMC Immunol. 2012 Jan 10;13:2.
2. Kim SH, et al. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6982-6. (Compound 8a)
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