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SCH-37370

CAS No. 117796-52-8

SCH-37370( SCH 37370 | SCH37370 )

Catalog No. M23344 CAS No. 117796-52-8

SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCH-37370
  • Note
    Research use only, not for human use.
  • Brief Description
    SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine.
  • Description
    SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SCH 37370 | SCH37370
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PAF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    117796-52-8
  • Formula Weight
    352.86
  • Molecular Formula
    C21H21ClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    CC(N(CC1)CCC1=C(c(cc1)c(CC2)cc1Cl)c1c2cccn1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kaminski JJ, Carruthers NI, Wong SC, Chan TM, Billah MM, Tozzi S, McPhail AT. Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorg Med Chem. 1999 Jul;7(7):1413-23. PubMed PMID: 10465415.
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