SC-560 ( SC-560; SC 560; SC560 )

Catalog No. M17399 CAS No. 188817-13-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SC-560
Note

Research use only, not for human use.
Brief Description

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
Description

SC-560 is a potent, orally active and selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 μM.1 Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme.
Synonyms

SC-560; SC 560; SC560
Pathway

Others
Target

Other Targets
Recptor

COX-1; COX-2
Research Area

Cancer|Inflammation/Immunology
Indication

——

CAS Number

188817-13-2
Formula Weight

352.74
Molecular Formula

C17H12ClF3N2O
Purity

98%
Solubility

DMSO : ≥ 100 mg/mL 283.49 mM; H2O : < 0.1 mg/mL
SMILES

COc1ccc(cc1)n1c(cc(n1)C(F)(F)F)c1ccc(cc1)Cl
Chemical Name

5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

1.Smith CJ, et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13313-8.

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