SC-236 ( SC236;SC58236 )

Catalog No. M12605 CAS No. 170569-86-5

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

SC-236
Note

Research use only, not for human use.
Brief Description

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.
Description

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM; displays >1,700-fold selectivity over COX-1 (IC50=17.8 uM); exhibits anti-inflammatory properties and potent antimetastatic activity both in vitro and in vivo.
Synonyms

SC236;SC58236
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX
Research Area

——
Indication

——

Chemical Information

CAS Number

170569-86-5
Formula Weight

401.80
Molecular Formula

C16H11ClF3N3O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O
Chemical Name

4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Penning TD, et al. J Med Chem. 1997 Apr 25;40(9):1347-65.
2. Lee A, et al. Cancer Res. 2006 Apr 15;66(8):4378-84.
3. Roche-Nagle G, et al. Br J Cancer. 2004 Jul 19;91(2):359-65.

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