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SBC-115337

CAS No. 423148-46-3

SBC-115337( —— )

Catalog No. M24388 CAS No. 423148-46-3

SBC-115337 is a PCSK9 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 357 In Stock
25MG 597 In Stock
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Biological Information

  • Product Name
    SBC-115337
  • Note
    Research use only, not for human use.
  • Brief Description
    SBC-115337 is a PCSK9 inhibitor.
  • Description
    SBC-115337 is a PCSK9 inhibitor.
  • In Vitro
    The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PSCK9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    423148-46-3
  • Formula Weight
    473.48
  • Molecular Formula
    C29H19N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 6mg/mL?(12.67mM;ultrasonic and warming and heat to 60℃)
  • SMILES
    O=C(C1=CC2=CC=CC=C2O1)NC3=CC=C(C(NC4=CC=C(C5=NC6=CC=CC=C6O5)C=C4)=O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lavecchia A , Cerchia C . Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy[J]. Future medicinal chemistry, 2019, 11(5):423-441.
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