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SBC-115337
CAS No. 423148-46-3
SBC-115337( —— )
Catalog No. M24388 CAS No. 423148-46-3
SBC-115337 is a PCSK9 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
|
| 10MG | 357 | In Stock |
|
| 25MG | 597 | In Stock |
|
| 50MG | 851 | In Stock |
|
| 100MG | 1152 | In Stock |
|
| 500MG | 2313 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSBC-115337
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NoteResearch use only, not for human use.
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Brief DescriptionSBC-115337 is a PCSK9 inhibitor.
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DescriptionSBC-115337 is a PCSK9 inhibitor.
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In VitroThe potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPSCK9
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Research Area——
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Indication——
Chemical Information
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CAS Number423148-46-3
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Formula Weight473.48
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Molecular FormulaC29H19N3O4
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Purity>98% (HPLC)
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SolubilityDMSO: 6mg/mL?(12.67mM;ultrasonic and warming and heat to 60℃)
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SMILESO=C(C1=CC2=CC=CC=C2O1)NC3=CC=C(C(NC4=CC=C(C5=NC6=CC=CC=C6O5)C=C4)=O)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lavecchia A , Cerchia C . Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy[J]. Future medicinal chemistry, 2019, 11(5):423-441.
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