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SB415286
CAS No. 264218-23-7
SB415286 ( SB-415286; SB 415286; SB415286 )
Catalog No. M17460 CAS No. 264218-23-7
SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 28 | In Stock |
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| 5MG | 43 | In Stock |
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| 10MG | 71 | In Stock |
|
| 25MG | 140 | In Stock |
|
| 50MG | 259 | In Stock |
|
| 100MG | 381 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB415286
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NoteResearch use only, not for human use.
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Brief DescriptionSB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.
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DescriptionSB-415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. Pharmacological GSK-3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes.
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SynonymsSB-415286; SB 415286; SB415286
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PathwayAngiogenesis
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TargetCDK
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RecptorGSK-3α , GSK-3β
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number264218-23-7
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Formula Weight359.72
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Molecular FormulaC16H10ClN3O5
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Purity98%
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SolubilityDMSO : ≥ 83.3 mg/mL; 231.57 mM
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SMILESOC1=C(Cl)C=C(NC2=C(C(=O)NC2=O)C2=C(C=CC=C2)[N+]([O-])=O)C=C1
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Chemical Name3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Coghlan MP, et al. Chem Biol, 2000, 7(10), 793-803.
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