SB-431542

CAS No. 301836-41-9

SB-431542( SB 431542 | SB431542 )

Catalog No. M13943 CAS No. 301836-41-9

SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 45 In Stock
10MG 73 In Stock
25MG 147 In Stock
50MG 266 In Stock
100MG 493 In Stock
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Biological Information

  • Product Name
    SB-431542
  • Note
    Research use only, not for human use.
  • Brief Description
    SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM.
  • Description
    SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM; also substantially inhibits ALK4 and 7, but not other ALKs; efficiently inhibits the ability of activated ALK4, ALK5, and ALK7 to phosphorylate Smad2; a selective inhibitor of endogenous activin and TGF-beta signaling but has no effect on BMP signaling, and has no effect on components of the ERK, JNK, or p38 MAP kinase pathways.(In Vitro):SB-431542 can inhibit the activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively.SB-431542 (0- 10 μM; 24 h) inhibits ALK5 and also the activin type I receptor ALK4 and the nodal type I receptor ALK7, which are very highly related to ALK5 in their kinase domains.SB-431542 (0.1, 0.5, 1, 5, or 10 μM; 30 min) efficiently inhibits Smad phosphorylation induced by TGF-β and activin but not BMP4.SB-431542 (0-10 μM) inhibits TGF-beta-induced transcription, gene expression, apoptosis, and growth suppression.(In Vivo):SB-431542 (subconjunctival; 0.5 and 2 mM; on days 1, 2, 3, and 7) inhibits scar formation after glaucoma filtration surgery in New Zealand rabbits.
  • In Vitro
    SB-431542 (GMP) (10 μM; 10 days) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation.SB-431542 (GMP) (10 μM) facilitates directed differentiation into midbrain dopamine neurons (mDA).SB-431542 (GMP) (3.8 μM) promotes differentiation of hPSCs to multipotent hematopoietic progenitors that arise from SOX17+ hemogenic endothelium in vitro. RT-PCRCell Line:Human pluripotent stem cells (hPSCs)Concentration:10 μM Incubation Time:10 days Result:Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.
  • In Vivo
    ——
  • Synonyms
    SB 431542 | SB431542
  • Pathway
    TGF-beta/Smad
  • Target
    TGFBR
  • Recptor
    ALK5|ALK4
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    301836-41-9
  • Formula Weight
    384.3875
  • Molecular Formula
    C22H16N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 40 mg/mL; Ethanol: 11.17 mg/mL (Need ultrasonic and warming)
  • SMILES
    O=C(N)C1=CC=C(C2=NC(C3=CC=C(OCO4)C4=C3)=C(C5=NC=CC=C5)N2)C=C1
  • Chemical Name
    Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Callahan JF, et al. J Med Chem. 2002 Feb 28;45(5):999-1001. 2. Inman GJ, et al. Mol Pharmacol. 2002 Jul;62(1):65-74. 3. Matsuyama S, et al. Cancer Res. 2003 Nov 15;63(22):7791-8. 4. Hjelmeland MD, et al. Mol Cancer Ther. 2004 Jun;3(6):737-45.
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