SB-399885

CAS No. 402713-80-8

SB-399885 ( SB399885 )

Catalog No. M14378 CAS No. 402713-80-8

SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 178 Get Quote
5MG 267 Get Quote
10MG 399 Get Quote
25MG 659 Get Quote
50MG 888 Get Quote
100MG 1251 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    SB-399885
  • Note
    Research use only, not for human use.
  • Brief Description
    SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors.
  • Description
    SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors; SB-399885 is a potent competitive antagonist (pA(2)=7.85), displays over 200-fold selectivity over other receptors; significantly increases extracellular acetylcholine levels in rat medial prefrontal cortex, exhibits cognitive enhancing properties in recognition models; also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
  • Synonyms
    SB399885
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    402713-80-8
  • Formula Weight
    446.34
  • Molecular Formula
    C18H21Cl2N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1=C(C=C(C=C1)S(=O)(=O)NC2=CC(=CC(=C2OC)Cl)Cl)N3CCNCC3.Cl
  • Chemical Name
    N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wesoowska A, et al. Eur J Pharmacol. 2008 Mar 17;582(1-3):88-93.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.
3. Hirst WD, et al. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19.
4. Wesoowska A, et al. Neuropharmacology. 2007 Apr;52(5):1274-83.
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