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SB-357134

CAS No. 219963-52-7

SB-357134 ( SB 357134;SB357134 )

Catalog No. M13506 CAS No. 219963-52-7

A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SB-357134
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5.
  • Description
    A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice.
  • Synonyms
    SB 357134;SB357134
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    219963-52-7
  • Formula Weight
    523.22
  • Molecular Formula
    C17H18Br2FN3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C1=CC=C(OC)C(N2CCNCC2)=C1)(NC3=CC(Br)=CC(F)=C3Br)=O
  • Chemical Name
    N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-(piperazin-1-yl)benzene-1-sulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8.
2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54.
3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306.
4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9.
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