SB-357134 ( SB 357134;SB357134 )

Catalog No. M13506 CAS No. 219963-52-7

A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5.

Purity : >98% (HPLC)

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Biological Information

Product Name

SB-357134
Note

Research use only, not for human use.
Brief Description

A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5.
Description

A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice.
Synonyms

SB 357134;SB357134
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

219963-52-7
Formula Weight

523.22
Molecular Formula

C17H18Br2FN3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=CC=C(OC)C(N2CCNCC2)=C1)(NC3=CC(Br)=CC(F)=C3Br)=O
Chemical Name

N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-(piperazin-1-yl)benzene-1-sulfonamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8.
2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54.
3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306.
4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9.

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